ExThera Medical is developing devices that address unmet clinical needs in the treatment of bloodstream infections. Its Seraph 100 Affinity Blood Filter is a first-of-its kind therapeutic device for treating bloodstream infections through binding and removal of bacteria, viruses, fungi, and certain sepsis mediators. The Seraph 100 blood filter received CE Mark approval in the EU in 2019, where it has been used for treatment of bloodstream infections including COVID-19. Seraph 100 is also available for the treatment of COVID-19 in the US under an FDA Emergency Use Authorization. The Seraph filter provides a long-awaited therapy that addresses the severe problem of drug-resistance, sepsis and the treatment of new and future microbial threats like the SARS-CoV-2 virus.